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Unlike Pinealon and Epitalon, which primarily target the pineal gland, DSIP is produced in the hypothalamus and works through a broader range of neurological pathways
Following this period, the mice were randomly divided into five treatment groups ( n = 5 per group): PBS, Mn/TI@mHSA, P-Mn@mHSA, P-Mn/TI@mHSA-N and P-Mn/TI@mHSA group, with the doses equivalent for 4 mg kg 1 of Mn/TI@mHSA
Intramuscular injections deliver a concentrated dose directly into the blood flow and provide the highest bioavailability of active ingredients and an immediate start of action
Focus on FP: Clostridium mixtures ( FP , Bacteroides faecis, Roseburia intestinalis) restore the Treg/Th17 balance in DSS-induced UC mice, increase IL-10 and IL-4 secretion, reduce pro-inflammatory factors such as TNF, IL-1, and IL-17, and repair the intestinal barrier (104)
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