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Though the body usually manufactures glutathione, environmental conditions, including pollution, stress, and poor food, can cause the body to lose glutathione

[4] Treatment of individuals with glutathione synthetase deficiency generally involve therapeutic treatments to address mild to severe symptoms and conditions

The vitamins C and E can also perform the same function alongside other purported benefits

485 These findings indicate that mitochondria iron overload, combined with ROS formation and subsequent ferroptosis, intensifies the cardiotoxic effects of DOX-induced cardiomyopathy and may be an important mechanism

Role of iron in brain development, aging, and neurodegenerative diseases