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Together, they form a complementary duo: NAD energizes the cell by powering mitochondrial ATP production, activating sirtuins, and supporting DNA repair

Immune, primarily antigen-presenting cells of myeloid origin as well as nonimmune cells (Qu et al., 2017) perceive extracellular HSP70 signaling via either C-type lectin or scavenger pattern recognition receptors (PRRs), thereby initiating cytokine release involved in innate immune responses (Murshid et al., 2018)

Collagen remodeling takes time, and inflammation can derail the process when it becomes chronic or excessive