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In patients with thalassemia, the high levels of growth differentiation factor 15 (GDF15) and erythroferrin can also inhibit the production of hepcidin (55, 56)

Vitamin B12 deficiency anemia: MedlinePlus Medical Encyclopedia

Acta 16 (1), 1928

Furthermore, lactate has emerged as a key player in immune regulation, with evidence pointing to its impact on immune cell function through mechanisms such as receptor signaling via GPR81 and histone lactylation, which are closely linked to its immune-modulatory effects [16]

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