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For the optic nerve crush rat models, the RGC shows a reduction of GPX4 and SLC7A11 expression, increased membrane density, reduced mitochondrial cristae, and increased lipid peroxide and iron levels, indicating RGC ferroptosis after optic nerve crush ( 2.6 Diabetic retinopathy DR is one of the most common microvascular complications of diabetes, which is a series of fundus diseases caused by retinal microvascular leakage and occlusion caused by chronic progressive diabetes

Am J Physiol 1994;267(5 Pt 1):G7949

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Tissues were counterstained with hematoxylin and mounted with DPX

parkeri were thawed on ice and diluted into fresh BMDM media to the desired concentration