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In vitro, 315 genes were downregulated and 137 upregulated after 1 week of doxy-induced Taz -KD (Fig
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Additionally, we identified insulin-like growth factor 1 receptor (IGF1R), AKT serine/threonine kinase 1 (AKT1), prostaglandin-endoperoxide synthase 2 (PTGS2), estrogen receptor alpha (ESR1), and epidermal growth factor receptor (EGFR) as potential targets, luteolin has an ideal affinity for these targets, suggesting that it may play a positive role in depression through multiple targets, mechanisms, and pathways
Under stress conditions leading to an elevated NADH/NAD+ ratio, GABA can be catabolized to -hydroxybutyrate (GHB) may mitigate excessive ROS accumulation by supplying NADPH via the action of -hydroxybutyrate dehydrogenase (GHBDH), supporting detoxifying enzymes, including those in the ascorbate/glutathione cycle