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Although the physiological function of ferroptosis remains poorly defined, it has been shown to be involved in various diseases 43,44,45

Inhibiting RAGE may suppress A accumulation in the brain parenchyma, and small molecule RAGE inhibitors are currently advancing to clinical trials [19, 300]

Epithalon also reduces intracellular reactive oxygen species, protects mitochondrial function under oxidative stress, and decreases apoptosis markers in aged or stressed models

topical research is earlier-stage but of interest