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Ethics declarations Ethics approval and consent to participate Manuscripts reporting studies involving human participants, human data, or human tissue must: The procedures and data collections in human study have been approved by Institutional Review Board of National Taiwan University Hospital (201507055MINC, 201712030RIND), and all participants signed a written informed consent form

doi: 10.1016/j.tube.2015.08.003 210 PanSJTanYLYaoSWXinYYangXLiuJet al

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