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In an animal study using 5-dihydrotestosterone + insulin treatment to simulate a miscarriage model in PCOS patients, NAC supplementation improved fetal survival rates in model mice by protecting mitochondrial function, restoring the balance of SOD1 and the Keap1/Nrf2 antioxidant response, reducing excessive ROS production, and mitigating placental formation defects [57]

These interactions may further impact complement activation, immune cell recruitment, and the amplification of inflammation (28)

A label change does not mean that a prior label was inadequate, and in fact label changes are an indication that our medical understanding is evolving. Four years after McNeil acted, the FDA required all acetaminophen manufacturers to add an alcohol alert to their products

Future investigations and intervention efforts must go beyond compartmentalization of these twin maladies, to target their shared biological mechanisms, particularly with the understanding that both conditions could possibly coexist in households and communities

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