Overall, high concentrations of reactive species produced by immune response, oxidative metabolism, and other environmental factors create a complex landscape of oxidative stress that the parasite has to deal with to maintain redox homeostasis for its survival in diverse hosts
doi: 10.1093/ajcn/81.1.230S
Once EDTA gains entry into the bloodstream, it binds with heavy metals like lead, cadmium and iron that can cause free radical damage to the arteries
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One potential approach to mitigate some of these challenges is the development of more selective targeting mechanisms, such as the use of bispecific antibodies or CAR-Ms engineered to recognize tumor-specific antigens, thereby minimizing off-target effects
