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Verkhratsky et al., 2022)

Specifically, the nuclear receptor proteins PPAR-alpha and PPAR-gamma have binding sites for Pinealon, allowing the peptide to regulate their synthesis.27 These proteins happen to play a key role in preventing Alzheimers pathogenesis, as they can downregulate the enzyme responsible for the development of amyloid beta plaques (a key feature of Alzheimers disease).28 29 Smaller bodies of research suggest that Pinealon may have other uses as well