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The hallmarks of cellular senescence, e.g., the appearance of senescence-associated -galactosidase (SA--gal) and heterochromatin foci (SAHF) as well as the increased expression of cell cycle inhibitor proteins, i.e., p16, p21, and p53, are also common markers of senescent immune cells, especially in Teff cells [154,155,156]

et al., Cerebrolysin reduces microglial activation in vivo and in vitro: a potential mechanism of neuro-protection, J Neuronal Transm 2000