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Description

Mapping the growth hormone-Stat5b-IGF-I transcriptional circuit

New studies are published, refining our understanding of its pharmacokinetics, pharmacodynamics, and potential applications

NNMT had previously been identified as upregulated in obese adipose tissue, several solid tumours, and ageing tissue more broadly, where its activity correlates with depleted SAM and elevated 1-methylnicotinamide (MNA)