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Concurrently, AMPK promotes mitochondrial biogenesis and repairs electron transport chain (ETC) complex activity by upregulating PGC-1 and mitochondrial transcription factor A (TFAM), effectively reducing superoxide anion generation caused by electron leakage

In neuromyelitis optica, Aquaporumab, a monoclonal antibody targeting AQP4-IgG, has demonstrated therapeutic potential [419]