Unlike Ipamorelin, GHRP-2 does modestly elevate cortisol and prolactin but at therapeutic doses, these elevations are typically well-tolerated and transient
Despite their popularity, there remains a paucity of human clinical evidence to support their safety and efficacy
The insulin/IGF-1 signaling pathway seems to be an evolutionarily well-conserved mechanism involved in the regulation of longevity in species ranging from metazoans to mammals [1, 2]
In addition, IGF-1 receptor sensitivity and activation of the post receptor pathway were not evaluated in the majority of the study enrolling long-lived subjects
(2008), measures of enzyme activity were used (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase), allowing a gauge of trauma response (proteolysis) and therefore the ability to further understand the mechanisms of action