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HNC is increasing worldwide, becoming more and more a challenging clinical problem

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While multiple advantageous aspects of the metabolic reprogramming for NRF2-addicted cancer cells have been described, metabolic liabilities resulting from NRF2-dependent reprogramming have also been investigated

Adequate iodine supply is crucial for preventing diseases of the mammary gland, as iodine lactones may protect against oxidative damage and inhibit cell division (Kupper and Gartner, 2007)