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Falcone M, Uribe AH, Papalazarou V, Newman AC, Athineos D, Stevenson K, et al

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VEGF inhibitors , including regorafenib and lenvatinib , are associated with arterial hypertension , which may be early-onset and dose-dependent

Why receptor subtype work matters for interpretation A common question is which receptor subtype is doing the work. A 2025 mechanistic study investigated AMY receptor subtype dependence and reported that cagrilintides body weight lowering effects depended on AMY1R and AMY3R in their models, which provides a more concrete receptor anchored explanation than general appetite language

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