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They also introduced mutations that optimized the enzymes overall kinetics with the goal of driving the gluten peptide levels below the threshold for toxicity, which is estimated at 50 milligrams per day, and doing so within a physiologically relevant timeframe (7)

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Plaque Excision and Grafting Removing the fibrous plaque and replacing it with graft material

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Because DSIP research is largely historical and not industrially funded, it lacks standardized research protocols, making comparison across studies difficult