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GHK-Cu is stable at physiological pH (6.57.5) but dissociates below pH 4 or above pH 9, releasing free copper, which can be pro-oxidant if unbound

Khavinson VKh, Kopylov AT, Vaskovsky BV, Ryzhak GA, Linkova NS

Most of the existing research on BPC-157 has been conducted in laboratory and animal settings

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The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]