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Research has established a strong correlation between lactate levels and both the precision of synaptic networks and neuronal excitability [186]

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Unlike free lipid peroxidation products such as MDA or 4-HNE, ox-LDL circulates systemically and engages in pathogenic signaling by activating Kupffer cells, promoting NLRP3 inflammasome activation, and inducing proinflammatory cytokines like TNF- and IL-1 [151, 152]

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Activation of RAGE/STAT3 pathway by methylglyoxal contributes to spinal central sensitization and persistent pain induced by bortezomib