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3 Ferroptosis and neurodegenerative diseases Iron is an essential trace element for maintaining brain function, playing vital roles in neuronal development, neurotransmitter synthesis, mitochondrial energy metabolism, myelin formation, and synaptic plasticity (Gao et al., 2025)

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86 Similarly, metabolomic analyses have characterized molecular changes in CFE reactions due to variations in extract source strain growth media and harvest conditions, 87 the impact of metabolites on CFE, 88 metabolic flux over time in differentially lysed extracts, 89 and batch-to-batch variability