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Interestingly, a disulfide bond is also found in the GCL from -proteobacteria (Hibi et al., 2004

It helps them fight off invaders without burning themselves out from their own "friendly fire" oxidative stress

Within the ER, hexose-6-phosphate dehydrogenase converts glucose-6-phosphate and NADP + to 6-phosphogluconate and NADPH in a single step, whereas this process in the cytosol requires two separate enzymes (G6PD and PGLS)

Efficient ROS production requires that the copper-binding site forms a chemical environment suitable for both oxidation states of copper

GLS1 knockdown can disrupt the balance between ATP production and consumption, leading to increased synthesis and breakdown of creatine phosphate, a reserve of high-energy phosphates in the brain [79]