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One way in which Htt aggregates could cause toxicity is through depleting ubiquitin, a protein that binds to misfolded proteins to promote their clearance through the ubiquitin-proteasome system ( Notably, the N-terminal 17-residue domain stretch of huntingtin folds into an amphipathic -helix in the presence of membranes ( -helix formation at the N-terminus

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doi: 10.1002/mco2.69 72 SliterDAMartinezJHaoLChenXSunNFischerTDet al