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Others may not be comfortable with their appearance and may use makeup, self-tanner, or skin dye to cover light patches

Concurrently, lactate accumulation contributes to an acidic tumor microenvironment that impairs T cell effector function, induces exhaustion, and suppresses proliferation [83]

However, Tregs can also adopt an inflammatory effector-like phenotype and lose their suppressive capacity due to chronic inflammation, metabolic reprogramming, tissue-specific reprogramming, and possibly insufficient IL-2 signaling 113,114

Pancreapedia: Exocrine Pancreas Knowledge Base 10:434443

doi: 10.1016/j.neurobiolaging.2006.06.025