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As of 2021, studies on glutathione's skin-lightening effects are sparse, small-scale, and often not peer-reviewed, limiting the ability to generalize results

doi: 10.3389/fvets.2023.1220213 Received 15 May 2023 Accepted 17 July 2023 Published 10 August 2023 Volume 10 - 2023 Edited by Huansheng Yang, Hunan Normal University, China Reviewed by Dan Yi, Wuhan Polytechnic University, China

The most reliable data comes from a 2020 systematic review and meta-analysis of 37 randomized controlled trials (about 2,300 participants)

In addition they suggest that the BSOr mutants are more resistant to heat inactivation than the wt virus and less dependent on GSH than the wt, likely because the BSOr capsids are more stable