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Nature Aging , 1, 760777

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substrates and inhibitors), 2) enzymatic modification, and 3) protein-protein interaction

Dihexa was synthesized as a small molecule compound that, in in vitro studies, demonstrated its ability to induce spinogenesis and synaptogenesis at picomolar concentrations

This multi-pathway activity resembles what we see with other biologic treatments in orthopedic surgery, where the therapeutic effect comes from coordinated biological response rather than a single drug-receptor interaction