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Reported Benefits

Deficiencies in E1 activators can have fatal consequences for cardiac proteostasis, as they disrupt the entire ubiquitination process

Cellular proteostasis is governed not only by molecular availability but also by spatial proximity and compartmentalization

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However, it is disappointing that IGF-1 has not been shown to play a very significant role in promoting tendon healing in clinical trials, which could reflect our poor understanding of the molecular mechanisms by which IGF-1 is involved in promoting tendon regenerative healing