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In addition, recent studies suggest that under certain conditions, such as hyperreduced CoQ pools and elevated mitochondrial membrane potential, reverse electron transport may occurwhereby electrons flow from ubiquinol (CoQ 10 H 2 ) back to complex I, generating NADH 110,111

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ROS and RNS production in physiological conditions is maintained at low levels [25, 26] and used to regulate various physiological functions, including cell signaling, homeostasis, vascular tone, and immune reactions [27]

Symptoms of a reaction might include skin rashes, itching, or digestive upset

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