TB-500: G-actin, cell migration and differentiation TB-500 operates through a completely different mechanism: Monomeric G-actin sequestration : maintains a free actin pool mobilizable for migration of repair cells (stem cells, fibroblasts, endothelial cells) Modulation of cell differentiation : publications have suggested effects on myocardial, neural and vascular differentiation Anti-fibrotic and anti-inflammatory effects (NF-B inhibition, cytokine modulation) Documented strengths: cardiac recovery post-ischemia, cutaneous healing, extracellular matrix remodeling, deep muscle recovery
Kodama, R
The application of synthetic cannabinoids (e.g., WIN55,212-2) were able to reduce the microglial release of these factors and directly act on primary astrocyte cells from mice to reduce hemichannel activation, preventing astrocytic uncoupling and maintaining gap junctions (Froger et al., 2009
As more research is done, KPV may become more widely available
Vitamin K The K vitamins exist naturally as K 1 (phylloquinone) in green vegetables and K 2 (menaquinone) produced by intestinal bacteria and K 3 is synthetic menadione