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mechanically, reactive oxygen species (ROS) can speed up skeletal muscle fatigue by reducing calcium sensitivity [8] and can decrease maximal calcium-activated force [9]

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doi: 10.1186/s12964-022-00909-0 10 ChenLZhangWChenDYangQSunSDaiZet al

Stracke H, Hammes HP, Werkmann D, Mavrakis K, Bitsch I, Netzel M, Geyer J, Kopcke W, Sauerland C, Bretzel RG, et al: Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats