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While early nonresponse is considered to be an indicator of later nonresponse and subsequent treatment resistance in schizophrenia [67], to our knowledge, the association between early nonresponse in first-episode samples and later sequential treatment failures and the status of conventionally defined TRS is yet to be established

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doi: 10.1111/acel.12706

This helps to locate properly the gaps resulting from insertion/deletion of the other amino acid residues (Fig 5)