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[142] reported that IL-37 suppressed Th2 and Th17 responses but had no significant regulatory effects on Th1 or Treg responses

doi: 10.1038/s41523-020-00212-6 76 TuomistoAEMakinenMJVayrynenJP

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Upon release, Nrf2 translocates to the nucleus and binds to the antioxidant response element (ARE) located in the promoter of genes coding for antioxidant/detoxifying enzymes and scavengers