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The supplement market offers B12 products containing 1,0005,000 micrograms per dose, vastly exceeding the recommended nutrient intake of 1.5 micrograms daily for adults

Limitations of traditional target discovery methods Traditional target discovery methods primarily focus on validating single targets and screening potential drugs, often employing techniques such as high-throughput screening (HTS) and in vitro experiments [234, 235]

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Potential long-term complications for the patients include duodenal ulcers, intestinal metaplasia with dysplasia, gastric adenocarcinoma (non-cardia intestinal-type), and spontaneous diffuse gastric cancer (29)