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Henning L, Unichenko P, Bedner P et al (2023) Overview article astrocytes as initiators of epilepsy

Schoenenberger and Monnier reported in the Proceedings of the National Academy of Sciences USA the isolation, sequence determination and synthesis of the active material, identified as the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, and demonstrated that intraventricular infusion of the synthetic compound in rabbits reproduced delta- and spindle-EEG enhancement under double-blind conditions (Schoenenberger & Monnier, 1977)

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doi:10.1016/s0196-9781(03)00040-8 Delta Sleep Inducing Peptide (DSIP) is a nonapeptide that was initially isolated from the cerebral venous blood of rabbits and hypothesized to act as a sleep aid