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Its pathogenesis primarily involves immune dysregulation, including breakdown of immune tolerance, alterations in the immune microenvironment, and dysregulation of T cell subsets (158, 159)

Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

10.1248/bpb.23.149 3 AraseY.IkedaK.MurashimaN.ChayamaK.TsubotaA.KoidaI.et al (1997)

A maintenance dose is the dose given regularly over the long term to maintain the desired effect after the initial response has been achieved