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Nevertheless, the underlying precise regulatory mechanisms require further elucidation

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We arent just observing the calcium paradox

Vitamin A, Lung Function, and Airway Hyperresponsiveness As retinoic acid (RA), the active form of vitamin A, and its signaling pathways play a role in smooth muscle differentiation during airway formation, vitamin A deficiency during the prenatal period leads to pulmonary defects and structural changes in the airway smooth muscles (ASM) of mice [123,224,225,226], which can contribute to non-inflammatory airway hyperreactivity [227]

& Mruk, D