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Ideally, blood tests (including full blood count, serum B12, folate, and possibly anti-intrinsic factor antibodies if pernicious anaemia is suspected) should be performed before starting supplements, as supplementation can affect test results

Mayo Clinic notes that there is no solid proof B12 injections help with weight loss in people who are not deficient

Anecdotal reports from research subjects and biohacking communities describe body composition improvements, increased subjective energy and mental clarity, and minimal side effects, though these uncontrolled observations require cautious interpretation and cannot substitute for rigorous clinical trials

For most compounds the headline safety question is what are the side effects? For 5-Amino-1MQ the honest headline is we do not yet know, and the correct response to not-knowing is conservatism documented doses, scheduled breaks, and a licensed clinician in the loop rather than assuming the absence of reported effects means the absence of risk

Again, B12 is harmless even at much higher doses, so its better to play it safe and inject too much rather than too little