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10.1111/j.1471-4159.2007.05177.x 97 NiliusB.PrenenJ.VoetsT.DroogmansG

Consequences of Excess Vitamin B12 Vitamin B12 is water-soluble, and excess amounts in the body can be easily excreted through urine, making it less toxic

Secondand this is arguably more importantevery time you puncture the stopper, you create a minuscule pathway for potential contaminants to enter

You Y, Qiu Y, Xu H, He R, Zhang L, Wang Z, Xia Y (2024) Effective and food-grade detoxification of multiple mycotoxins using yeast expressed manganese peroxidases