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A specific oxidoreductase, previously known as apoptosis-inducing-factor mitochondrial-2 (AIFM2), capable of recycling reduced ubiquinol (Co-enzymeQ 10 H 2 ) from ubiquinone at the expense of NAD(P)H, has been presented as a potential ferroptosis inhibitor due to the fact that its overexpression complements the loss of GPx4 in PFA1 and human fibrosarcoma (66, 67)
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Secretion: ABCG2, OAT1/3 (basolateral), MRP4, and NPT1/4 (apical) ensure urate secretion from blood into the tubular lumen (Yu et al., 2023
[DOI] [PMC free article] [PubMed] [Google Scholar] 180.An X., Yu W., Liu J., Tang D., Yang L., Chen X