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rather, multiple susceptibility loci interact with environmental elements to modulate disease risk

Phaeomelanin: This is a yellow or red pigment

Aggregation or precipitation in solution, reducing available monomeric peptide

Regarding nonprimarily affected processes, several compounds also had promising outcomes: dantrolene (targeting calcium-signaling dysregulation), sodium butyrate (modulating transcription through HDAC inhibition), creatine (improving defective energy production), and several modulators of neurotransmission (such as citalopram and riluzole) [118, 148, 158, 170, 171, 176]

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