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Immediate receptor binding (seconds to minutes), intracellular signaling cascade propagation (minutes to hours), gene expression changes (hours to days), protein synthesis and accumulation (days to weeks), cellular and tissue-level effects (weeks to months)

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Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells