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2009 IASLC, 2009

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Twelve elderly nursing home patients with cognitive dysfunction (2 males, 10 women

Increased levels of ROS in the blood and/or impaired antioxidant ability in chronically unwell patients with muscle loss have both been related to muscle wasting and ROS as powerful inducers of the UPS pathway, respectively

The observed alleviation of this inhibition (by NaBH 4 -reduced gliotoxin), in the presence of added GSH, supports the proposal that intracellular GSH depletion is a consequence of gliT disruption, when growth occurs in the presence of exogenous gliotoxin