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A 2.5 mg track has short direct data and real-world support for stable maintainers, but continuing tirzepatide has much stronger evidence than stopping. At week 112, stepping down to 5 mg preserved 16.6% weight loss versus 21.9% on the top dose and 9.9% on placebo

12 weeks 3 vials 12 full weekly maintenance doses

in turn, altered gut flora can also affect thyroid function

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