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Author Contributions Mette JF Nielsen, Britt W Lauenborg and Viera Kupov contributed to the design, protocol and conduct of the studies
Based on a 5-km time improvement of 2.5% or about 30 seconds (SD = 1 minute) with Protandim , and no improvement in the placebo group, about 34 runners in total were needed (Effect size for ANOVA = f = 0.25, which is moderate, statistical power = 80%, two-sided alpha error probability = 5%, two measurements per group, two groups, correlation amongst repeated measures = 0.50, F-test Family, ANOVA repeated measures, within-between interaction, G*Power 3.1.2, Universitt Kiel, Germany)
In particular cases, hypothyroidism may also be responsible for refractory gastrointestinal bleeding in routine treatment [144]
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