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Within these cells, the miRNAs downregulate apoptotic Markers, including cleaved caspase 3 and pro-apoptotic proteins such as Bax, while simultaneously upregulating anti-apoptotic proteins like Bad and Bcl2

(1)Prousky, J., 2008, The Treatment of Pulmonary Diseases and Respiratory-Related Conditions With Inhaled (Nebulized or Aerosolized) Glutathione, Evid Based Complement Alternat Med

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Per the applicant, the Total Ankle Talar Replacement is a patient specific, metallic spacer that is a solid, polished replica of a patient's physiologic talus and intended to articulate to the surrounding native bone anatomy (that is, calcaneus and navicular)