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While vitamin B12 supports cellular energy metabolism, supplementing B12 in a patient who is not deficient does not increase metabolic rate or cause fat loss

DebRoy, T., Wei, H

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While the thought of an injection can be worrying, most patients find the procedure causes only mild, short-lived discomfort

"And it's not because of any magic it's because these are natural substances that our bodies make and are familiar with, so that's what gives them this incredible safety profile." The FDA, however, has publicly stated that there is not enough evidence from human clinical trials on the safety or efficacy of these drugs