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Because of the hypothesised abnormalities in oxidative stress and suggested links between initial inflammation, glutamate excitotoxicity and neuronal dysfunction/loss [25], our additional interest was in, GSH, glutamate and glutamine, and total choline as biomarkers of these processes

We collected data on of 3,203 adults aged 3570 years old participated in the early phase of the PERSIAN Dena cohort study (PDCS) (Fig

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