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12 Abnormally high levels of the neurofilament light chain protein in blood, a biomarker of damaged neurons, were found to start an average of 22 years before the median estimated age of symptom onset

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Gao 2023 (human GLP1R-variant series) puts a number on it at the GLP-1 receptor: cAMP output saturates at roughly 10% (103%) receptor surface expression, so full effect sits far below full occupancy

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

2020;219:e202004003