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Though further large-scale studies are needed, the early evidence supporting peptides and supplements is compelling, especially when these tools are used in conjunction with evidence-based treatments such as behavioral therapy and medication-assisted treatment

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Thus, after peripheral nerve injury, many pathological changes occur, including the degeneration of nerve cells and axons and the dedifferentiation of Schwann cells, the release of inflammatory and cytotoxic mediators, the infiltration and activation of immune cells in the inflamed area, as well as microglia- and astrocyte-mediated neuroinflammatory processes at the peripheral and central nervous system levels [45,46,47,48,49,50,57]