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Sorafenib induces ferroptosis by targeting the cystine/glutamate anti-transport system Xc- [154,155,156,157], an effect that impinges on cystine uptake, thereby preventing subsequent synthesis of glutathione (GSH), the major intracellular antioxidant, preventing GPX4 activation [158, 159], and can trigger ER stress and ferroptosis

Knox S, Downer B, Haas A, Ottenbacher KJ

doi:10.5603/GP.a2020.0173

Mechanism: Epithalon appears to restore the sensitivity of the pineal gland to environmental light cues, helping it produce melatonin at the correct times

When the spinal canal narrows, the spinal cord itself can be compressed